Abstract: Iron tailings sand substituting quartz sand used as the aggregate in cement-based grouting material was studied. The effects of substitution rate of iron tailings sand, water-cement ratio and cement-sand ratio on the workability and mechanical property of the cement-based grouting material were studied. And the microscopic structure was analyzed by SEM. The experimental result shows that the larger the substitution rates of iron tailings sand, the worse the workability of grouting material. On the other hand, the right amount of iron tailings sand can improve compressive strength of grouting material for every age. When the substitution rate is 40%, the properties of grouting materials meet the standard requirements. The fluidity of grouting material increases as the water-cement ratio is increasing. The maximum compressive strength of each age is gotten when the water-cement ratio is 0.29. With decreasing of the cement-sand ratio, the fluidity of grouting material decreases. The graph trend of compressive strength is a bell-shape in the distribution curve figure when the cement-sand ratio is 0.9, the compressive strength can reach the highest value.