Abstract: With the development of construction industrialization, precast concrete panels are applied more and more widely. Panel adhesive is used for assemblage and binding the precast concrete panels. When its tensile strength is not high enough, it will cause problems like cracking. In order to improve its tensile strength, the influence of mixing talc powder, slag powder and metakaolin on the tensile bond strength of panel adhesive were studied based on previous research. The orthogonal experiment results showed that, adding talc powder and slag powder could improve the tensile bond strength effectively, but the large amount of metakaolin could decrease the tensile strength. The optimizing experiment results showed that the optimal mix ratio of talc powder and slag powder was 30% and 20% respectively.